Tronidaze

Therapeutic Group: Anti-Infection Drugs Chemical Composition: Metronidazole License by : Unipharma Dosage form: Film Coated Tablets
Information about Tronidaze

COMPOSITION :

Each F.C tablet contains: 250 or 500 mg Metronidazole

INDICATIONS:

TRONIDAZE is indicated for:

  • - Treatment of symptomatic Trichomoniasis in females and males when the presence of the trichomonad has been confirmed, and asymptomatic Trichomoniasis in females when it‘s associated with endocervicitis, cervicitis, or cervical erosion. Asymptomatic sexual partners of treated patients should be treated simultaneously to prevent reinfection of the partner.

  • - Treatment of acute intestinal amebiasis (Amebic dysentery) and amebic liver abscess.

- Treatment of Anaerobic Bacterial Infections that are proven or strongly suspected to be caused by susceptible bacteria.

CONTRAINDICATIONS:

Patients with history of hypersensitivity to Tronidaze or other nitroimidazole derivatives.

ADVERSE REACTIONS:

headache, syncope, dizziness, vertigo, ataxia, irritability,depression, weakness, insomnia, nausea, anorexia, vomiting, diarrhea, abdominal cramps, constipation, unpleasant metallic taste, glossitis, urticaria, rash,pruritus, neutropenia (rarely), thrombocytopenia, Stevens-Johnson Syndrome,nasal congestion, dryness of the mouth and vagina, fever, dysuria, polyuria,proliferation of Candida in the vagina, decrease of libido, proctitis, fleeting joint pains, rare cases of pancreatitis.

DOSAGE and ADMINISTRATION:

Trichomoniasis: 2 g given either as a single dose or in 2 divided doses of 1 g each, given in the same day or 250 mg 3 times daily for seven consecutive days. The dosage regimen should be individualized.


Amebiasis: For acute intestinal amebiasis: 750 mg orally 3 times daily for 5 to 10 days.For amebic liver abscess: 500 mg or 750 mg orally 3 times daily for 5 to 10 days.


Anaerobic Bacterial Infections: In most serious anaerobic infections, intravenous Tronidaze is usually administered initially. The usual oral dosage is 500 mg every 6 hours for 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment

For patients with severe hepatic impairment, the dose should be reduced by 50%.

In elderly, and patients with decreased renal function monitoring for Tronidaze associated adverse events is recommended.

Supplementation of Tronidaze dose following hemodialysis should be considered.


PACKAGING: 20 F.C.Tablets.

STORAGE CONDITIONS: Store below 25°C and protect from light.